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MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Engineering 2022, Volume 16, Issue 9,   Pages 162-175 doi: 10.1016/j.eng.2021.07.020

Abstract: We previously demonstrated that the chromosome 19 microRNA cluster (C19MC) was associated with tumorIn the current study, we aim to explore the role of miR-516a-3p—an identical mature microRNA (miRNAMixOmic DIABLO analysis showed a close correlation and strong cluster consistency between the proteomics

Keywords： Hepatocellular carcinoma     miRNA cluster     Exosome     Multi-omics    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract:

This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Design of tandem genes cluster for isoflavone engineering

Xunli XIA PhD , Guangxiao YANG PhD , Guangyuan HE PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 292-296 doi: 10.1007/s11684-009-0057-y

Abstract: In this paper, a universal effective novel method of constructing tandem genes cluster for isoflavoneA tandem genes cluster () of secondary metabolites of plant isoflavones was constructed by using the

Keywords： isoflavones engineering     secondary metabolism     tandem genes cluster    

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Understanding high-emitting households in the UK through a cluster analysis

Xinfang WANG, Ming MENG

Frontiers in Energy 2019, Volume 13, Issue 4,   Pages 612-625 doi: 10.1007/s11708-019-0647-6

Abstract: It applies a cluster approach, aiming to identify whether the high emitters comprise clusters where householdsin each cluster share similar characteristics but are different from the others.Policymakers should target each high-emitter cluster differently to reduce CO emissions from energy

Keywords： cluster analysis     emissions reduction     energy use     high emitters     household energy consumption     socioeconomic    

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Scaling up of cluster beam deposition technology for catalysis application

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1360-1379 doi: 10.1007/s11705-021-2101-7

Abstract: Many research works have demonstrated that the combination of atomically precise cluster deposition andtheoretical calculations is able to address fundamental aspects of size-effects, cluster-support interactions, and reaction mechanisms of cluster materials.In this review, we introduce the latest progress on three types of cluster source which have the mostsource, and matrix assembly cluster source.

Keywords： nanoparticle     cluster     cluster beam deposition     magnetron sputtering     heterogeneous catalysis    

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MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus

Lingyan HOU, Yun LU, Ying LI, Li LI

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 99-105 doi: 10.1007/s11783-013-0490-7

Abstract: MicroRNA (miRNA) is a class of regulatory gene, which has been shown to be a good biomarker for manyIn this study, two types of microarrays were used to test the 17β-estradiol (E2) induced miRNA expression

Keywords： estrogen     microRNA (miRNA)     microarray     biomarker    

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Fuzzy cluster analysis of tapered roller bearing vibration

Liu Jinjun,Xia Xintao,Zhang Lihong

Strategic Study of CAE 2008, Volume 10, Issue 7,   Pages 112-117

Abstract:

By using the fuzzy cluster analysis of grey system theory to analysis

Keywords： tapered roller bearing     vibration     fuzzy cluster analysis    

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Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 242-254 doi: 10.1007/s11684-013-0256-4

Abstract:

Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including cellular interaction, cytokines, microRNA and stem cells. All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma.

Keywords： hepatocellular carcinoma     hepatitis     cytokine     stem cell     miRNA    

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Cluster voltage control method for “Whole County” distributed photovoltaics based on improved differential

Frontiers in Energy   Pages 782-795 doi: 10.1007/s11708-023-0905-8

Abstract: To address the problems, this paper proposes a cluster voltage control method for distributed photovoltaicThen, in each cluster, based on the control strategy of “reactive power compensation first, active power

Keywords： distributed photovoltaics (DPVs)     cluster partitioning     improved differential evolution algorithm     voltage    

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Determination of the principal factors of river water quality through cluster analysis method and its

Liang GUO, Ying ZHAO, Peng WANG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 2,   Pages 238-245 doi: 10.1007/s11783-011-0382-7

Abstract: through the analysis of the weight relation between influencing factors and forecasting object using cluster

Keywords： water quality forecast     principal factor     cluster analysis method     artificial neural network    

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A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–H

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10,   Pages 1485-1492 doi: 10.1007/s11705-022-2169-8

Abstract: In present work, methane activation on MgO supported Ni–M (M = Fe, Co, Cu, Pd, Pt) cluster was exploredthrough detailed density functional theory calculations, compared to pure Ni cluster.CH4 adsorption on Cu promoted Ni cluster requires overcoming an energy of 0.07 eV, indicatingDoping elements of the same period in Ni cluster, such as Fe, Co and Cu, for C–H bond activation followsConsequently, C–H bond activation demands a lower energy barrier on Ni–Pt cluster.

Keywords： CH4 dissociation     Ni–M     C–H bond activation     charge transfer    

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Vacuum promotes metabolic shifts and increases biogenic hydrogen production in dark fermentation systems

Haifa RAJHI,Daniel PUYOL,Mirna C. MARTÍNEZ,Emiliano E. DÍAZ,José L. SANZ

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3,   Pages 513-521 doi: 10.1007/s11783-015-0777-y

Abstract: The successful operation of any type of hydrogen-producing bioreactor depends on the performance of the microorganisms present in the system. Both substrate and partial gas pressures are crucial factors affecting dark fermentation metabolic pathways. The main objective of this study was to evaluate the impact of both factors on hydrogen production using anaerobic granular sludge as inoculum and, secondly, to study the metabolic shifts of an anaerobic community subjected to low partial gas pressures. With this goal in mind, seven different wastewater (four synthetic media, two industrial wastewater, and one domestic effluent) and the effect of applying vacuum on the systems were analyzed. The application of vacuum promoted an increase in the diversity of hydrogen-producing bacteria, such as , and promoted the dominance of acetoclastic- over hydrogenotrophic methanogens. The application of different media promoted a wide variety of metabolic pathways. Nevertheless, reduction of the hydrogen partial pressure by application of vacuum lead to further oxidation of reaction intermediates irrespective of the medium used, which resulted in higher hydrogen and methane production, and improved the COD removal. Interestingly, vacuum greatly promoted biogenic hydrogen production from a real wastewater, which opens possibilities for future application of dark fermentation systems to enhance biohydrogen yields.

Keywords： dark fermentation     biohydrogen     wastewaters     vacuum    

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Monte Carlo simulation of the diffusion-limited aggregating process of particle suspension systems

Jiajing XU, Lin ZHANG, Yongjian TANG, Wei DAI, Wenwen SHAN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 270-274 doi: 10.1007/s11705-009-0273-7

Abstract: In this paper, the aggregating process was simulated with off-lattice diffusion-limited cluster-clusteranalysis of gyration radius distribution and the existence of a scaling distribution of the reduced cluster

Keywords： cluster-cluster aggregation     distribution function     relationship     process     universal    

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Heterometallic cluster-based organic frameworks as highly active electrocatalysts for oxygen reduction

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 5,   Pages 570-580 doi: 10.1007/s11705-022-2247-y

Abstract: The oxygen reduction reaction and oxygen evolution reaction catalytic activities of heterometallic cluster-basedFurthermore, the analysis of the electron structure indicates that constructing a mixed-metal clusterIn conclusion, the mixed-metal cluster strategy provides a new approach to further design and synthesize

Keywords： bimetallic metal–organic frameworks     bifunctional electrocatalyst     density functional theory     oxygen reduction reaction     oxygen evolution reaction    

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Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 136-148 doi: 10.1007/s11684-020-0756-y

Abstract: Precise identification of HIV transmission among populations is a key step in public health responses. However, the HIV transmission network is usually difficult to determine. HIV molecular networks can be determined by phylogenetic approach, genetic distance-based approach, and a combination of both approaches. These approaches are increasingly used to identify transmission networks among populations, reconstruct the history of HIV spread, monitor the dynamics of HIV transmission, guide targeted intervention on key subpopulations, and assess the effects of interventions. Simulation and retrospective studies have demonstrated that these molecular network-based interventions are more cost-effective than random or traditional interventions. However, we still need to address several challenges to improve the practice of molecular network-guided targeting interventions to finally end the HIV epidemic. The data remain limited or difficult to obtain, and more automatic real-time tools are required. In addition, molecular and social networks must be combined, and technical parameters and ethnic issues warrant further studies.

Keywords： human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention    

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Title Author Date Type Operation

MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Design of tandem genes cluster for isoflavone engineering

Xunli XIA PhD , Guangxiao YANG PhD , Guangyuan HE PhD ,

Journal Article

Understanding high-emitting households in the UK through a cluster analysis

Xinfang WANG, Ming MENG

Journal Article

Scaling up of cluster beam deposition technology for catalysis application

Journal Article

MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus

Lingyan HOU, Yun LU, Ying LI, Li LI

Journal Article

Fuzzy cluster analysis of tapered roller bearing vibration

Liu Jinjun,Xia Xintao,Zhang Lihong

Journal Article

Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Journal Article

Cluster voltage control method for “Whole County” distributed photovoltaics based on improved differential

Journal Article

Determination of the principal factors of river water quality through cluster analysis method and its

Liang GUO, Ying ZHAO, Peng WANG

Journal Article

A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–H

Journal Article

Vacuum promotes metabolic shifts and increases biogenic hydrogen production in dark fermentation systems

Haifa RAJHI,Daniel PUYOL,Mirna C. MARTÍNEZ,Emiliano E. DÍAZ,José L. SANZ

Journal Article

Monte Carlo simulation of the diffusion-limited aggregating process of particle suspension systems

Jiajing XU, Lin ZHANG, Yongjian TANG, Wei DAI, Wenwen SHAN,

Journal Article

Heterometallic cluster-based organic frameworks as highly active electrocatalysts for oxygen reduction

Journal Article

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Journal Article